Zoledronic acid modulates function and differentiation of myeloid cells.
نویسنده
چکیده
Acute Lymphoblastic Leukemia 1212-1221 The outcome of molecular-cytogenetic subgroups in pediatric T-cell acute lymphoblastic leukemia: a retrospective study for patients treated according to DCOG or COALL protocols Martine van Grotel, Jules P.P. Meijerink, H. Berna Beverloo, Anton W. Langerak, Jessica G.C.A.M. Buys-Gladdines, Pauline Schneider, Tim S. Poulsen, Monique L. den Boer, Martin Horstmann, Willem A. Kamps, Anjo J.P. Veerman, Elisabeth R. van Wering, Max M. van Noesel, Rob Pieters
منابع مشابه
تاثیر داروی زولدرونیک اسید در بیان و متیلاسیون ژن BSP در طول تمایز استئوبلاستیک سلولهای بنیادی مزانشیمی
Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs) was evaluated. Materials and Methods: In this experimental study, MSCs were isolated from human bone marrow. For osteogenic differentiation,...
متن کاملEvaluation of Changes in Global DNA Methylation during Osteoblastic Differentiation of Mesenchymal Stem Cells: A Laboratory Study
Background and Objectives: Control processes in osteoblastic differentiation of mesenchymal stem cells are not yet fully understood. Epigenetic mechanisms, especially the methylation of CpG Islands in the promoter of genes, are considered as one of the most important control mechanisms in stem cell differentiation. In the process of differentiation, it is debated whether only the methylation of...
متن کاملمقایسه بیان کمّی فاکتور نسخه‌برداری RUNX2 در تمایز سلولهای بنیادی مزانشیمی با محیط تمایزی استئوبلاستی و داروی زولدرونیک اسید
Background and Objectives : RUNX2 is the most specific transcription factor in osteoblastic differentiation of MSCs. In this research, RUNX2 expression was quantified in MSCs differentiated by osteogenic differentiation medium (ODM) and zoledronic acid (ZA). Materials and Methods: In this experimental study, hMSCs were treated by osteogenic differentiation medium and ZA. RNA extraction was ...
متن کاملاثر زهر زنبور عسل برروی قدرت تمایزی-D آلفا توکوفرول سوکسینات (ویتامین E) در رده سلول سرطانی حاد پرومیلوسیت HL-60
Background: Acute promyelocytic leukemia is the most malignant type of myeloid leukemia characterized by chromosomal translocation (15 and 17) and also blocking the cells in promyelocytic stage of differentiation into myeloid. Nowadays, differentiation therapy is used to treat leukemia. Previous studies indicate that vitamin E inhibits proliferation and also induces differentiation of HL-60 cel...
متن کاملAnalysis of Promyelocytic Leukemia in Human Embryonic Carcinoma Stem Cells During Retinoic Acid-Induced Neural Differentiation
Background: Promyelocytic leukemia protein (PML) is a tumor suppressor protein that is involved in myeloid cell differentiation in response to retinoic acid (RA). In addition, RA acts as a natural morphogen in neural development. Objectives: This study aimed to examine PML gene expression in different stages of in vitro neural differentiation of NT2 cells, and to investigate the possible role o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Haematologica
دوره 91 9 شماره
صفحات -
تاریخ انتشار 2006